Multiple myeloma causes massive destruction of the extracellular matrix in bone, and is consequently one of the most serious bone diseases. Damage is induced by stimulating extensive osteolytic activity of osteoclasts while blocking bone regeneration. Our group is interested in the molecular dissection of signaling pathways which exert bone anabolic and anti-tumor effects of biophysical stimuli in myeloma bone disease. We focus our studies on candidates for a hub orchestrating mechanoresponsive bone remodeling. Our group further conducts clinical trials to show how biophysical stimuli in form of whole-body vibration exercise or impact training induce bone regeneration in patients with multiple myeloma.
Ziouti F*, Rummler M*, Steyn B, Thiele T, Seliger A, Duda GN, Bogen B, Willie BM*, Jundt F*, Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease. International Journal of Molecular Sciences, 2021, 22:3840. *contributed equally
Rummler M*, Ziouti F*, Bouchard AL, Brandl A, Duda GN, Bogen B, Beilhack A, Lynch ME, Jundt F*, Willie BM*, Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model of myeloma bone disease. Acta Biomaterialia, 2021, 119:247-258. *contributed equally
Seefried L, Genest F, Strömsdörfer J, Engelmann B, Lapa C, Jakob F, Baumann FT, Sperlich B, Jundt F, Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance. J Bone Oncology, 2020, 25:100323.
Ziouti F, Prates Soares A, Moreno-Jiménez I, Rack A, Bogen B, Cipitria A, Zaslansky P, Jundt F, An early myeloma bone disease model in skeletally-mature mice as a platform for biomaterial characterization of the extracellular matrix. Journal of Oncology, 2020:3985315.
Ziouti F, Ebert R, Rummler M, Krug M, Müller-Deubert S, Lüdemann M, Franz J, Willie BM, Jundt F, Notch signaling is activated through mechanical strain in human bone marrow-derived mesenchymal stromal cells. Stem Cells International, 2019:5150634.