Deutsch Intern
Institute for Clinical Epidemiology and Biometry

Dr. Rebecca Roth

kurzer Lebenslauf

seit 2022 Wissenschaftliche Mitarbeiterin, Institut für Klinische Epidemiologie und Biometrie, Universität Würzburg
2015-2022 Wissenschaftliche Mitarbeiterin, Institut für Medizinische Statistik und Bioinformatik, Universität zu Köln
2011-2015  Wissenschaftliche Mitarbeiterin, PMV forschungsgruppe, Universität zu Köln
2009 GMDS-Förderpreis in Medizinischer Epidemiologie (Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie, GMDS)
2008 Promotion zum Dr. sc. hum. (summa cum laude), Ruprecht-Karls-Universität, Heidelberg
2005-2011 Wissenschaftliche Mitarbeiterin, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
2000-2005 Diplomstudium Wirtschaftsmathematik, Technische Universität Kaiserslautern

wissenschaftliche Schwerpunkte

Biometrie, Epidemiologie, Versorgungsfoschung, Patient-Reported-Outcomes

Hauptpublikationen der letzten Jahre

 Schwarzbach C.J., Eichner F.A., Rücker V., Hofmann A.-L., Keller M., Audebert H.J. et al.
The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial.
The Lancet Neurology. 2023. https://doi.org/10.1016/S1474-4422(23)00216-8

Sibert NT, Pfaff H, Breidenbach C, Wesselmann S, Roth R, […], Kowalski C. Variation across operating sites in urinary and sexual outcomes after radical prostatectomy in localized and locally advanced prostate cancer. World J Urol. 2022 Mar 26. doi: 10.1007/s00345-022-03985-6. Epub ahead of print. PMID: 35347412.

Podda M, Kovacs M, Hellmich M, Roth R, […], Cornely OA. A randomised controlled multicentre investigator-blinded clinical trial comparing efficacy and safety of surgery versus complex physical decongestive therapy for lipedema (LIPLEG). Trials. 2021 Oct 30;22(1):758. doi: 10.1186/s13063-021-05727-2. PMID: 34717741; PMCID: PMC8557553.

Plata C, Nellessen M, Roth R, […], Wetsch WA. Impact of video quality when evaluating video-assisted cardiopulmonary resuscitation: a randomized, controlled simulation trial. BMC Emerg Med. 2021 Aug 21;21(1):96. doi: 10.1186/s12873-021-00486-4. PMID: 34418968; PMCID: PMC8380108.

Oberste M, Pusch LM, Roth R, […], Neuhann F. Protocol of the Cologne Corona Surveillance (CoCoS) Study- a prospective population-based cohort study. BMC Public Health. 2021 Jul 2;21(1):1295. doi: 10.1186/s12889-021-11206-9. PMID: 34215236; PMCID: PMC8253235.

Wetsch WA, Ecker HM, Scheu A, Roth R, Böttiger BW, Plata C. Video-assisted cardiopulmonary resuscitation: Does the camera perspective matter? A randomized, controlled simulation trial. J Telemed Telecare. 2021 Jun 25:1357633X211028490. doi: 10.1177/1357633X211028490. Epub ahead of print. PMID: 34170206.

Roth R, Dieng S, Oesterle A, Feick G, Carl G, […], Kowalski C. Determinants of self-reported functional status (EPIC-26) in prostate cancer patients prior to treatment. World J Urol. 2021 Jan;39(1):27-36. doi: 10.1007/s00345-020-03097-z. Epub 2020 Feb 10. PMID: 32040715; PMCID: PMC7858203.

Kowalski C, Roth R, Carl G, Feick G, Oesterle A et al. A multicenter paper-based and web-based system for collecting patient-reported outcome measures in patients undergoing local treatment for prostate cancer: first experiences. J Patient Rep Outcomes. 2020 Jul 13;4(1):56. doi: 10.1186/s41687-020-00224-7. PMID: 32661594; PMCID: PMC7359206.

Breidenbach C, Roth R, Ansmann L, Wesselmann S, Dieng S, […], Kowalski C. Use of psycho-oncological services by prostate cancer patients: A multilevel analysis. Cancer Med. 2020 Jun;9(11):3680-3690. doi: 10.1002/cam4.2999. Epub 2020 Mar 31. PMID: 32233081; PMCID: PMC7286449.

Scheffler M, Ihle MA, Hein R, […], Wolf J. K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways. J Thorac Oncol. 2019 Apr;14(4):606-616. doi: 10.1016/j.jtho.2018.12.013. Epub 2018 Dec 31. PMID: 30605727.

Ujeyl M, Köster I, Wille H, Stammschulte T, Hein R, […] Schubert I. Comparative risks of bleeding, ischemic stroke and mortality with direct oral anticoagulants versus phenprocoumon in patients with atrial fibrillation. Eur J Clin Pharmacol. 2018 Oct;74(10):1317-1325. doi: 10.1007/s00228-018-2504-7. Epub 2018 Jun 16. PMID: 29909576.

Hein R, Schubert I. Age-Linked Treatment Rates. Dtsch Arztebl Int. 2016 Apr 22;113(16):287-8. doi: 10.3238/arztebl.2016.0287b. PMID: 27159145; PMCID: PMC4985521.

Simon ST, Kloke M, Alt-Epping B, […] Hein R, […] Voltz R. EffenDys-Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Patients With Advanced Cancer: A Multicenter, Open-Label, Randomized, Morphine-Controlled, Crossover, Phase II Trial. J Pain Symptom Manage. 2016 Nov;52(5):617-625. doi: 10.1016/j.jpainsymman.2016.05.023. Epub 2016 Sep 30. PMID: 27693898.

Fehringer G, Kraft P, Pharoah PD, […] Hein R, […], Haiman CA, Henderson BE, Hung RJ; Ovarian Cancer Association Consortium (OCAC); PRACTICAL Consortium; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Colorectal Transdisciplinary (CORECT) Study; African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC). Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res. 2016 Sep 1;76(17):5103-14. doi: 10.1158/0008-5472.CAN-15-2980. Epub 2016 Apr 20. PMID: 27197191; PMCID: PMC5010493.

Jazmati N, Hein R, Hamprecht A. Use of an Enrichment Broth Improves Detection of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae in Clinical Stool Samples. J Clin Microbiol. 2016 Feb;54(2):467-70. doi: 10.1128/JCM.02926-15. Epub 2015 Nov 25. PMID: 26607984; PMCID: PMC4733169.

Michels S, Scheel AH, Scheffler M, […], Hein R, […], Wolf J. Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients. J Thorac Oncol. 2016 Jan;11(1):122-7. doi: 10.1016/j.jtho.2015.09.016. PMID: 26762747.

Bolton KL, Tyrer J, Song H, […], Hein R, […], Gayther SA. Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2016 Jan;48(1):101. doi: 10.1038/ng0116-101b. Erratum for: Nat Genet. 2010 Oct;42(10):880-4. Brook-Wilson, Angela [corrected to Brooks-Wilson, Angela]. PMID: 26711112.

Lin WY, Camp NJ, Ghoussaini M, […], Hein R, […], Cox A. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet. 2015 Jan 1;24(1):285-98. doi: 10.1093/hmg/ddu431. Epub 2014 Aug 28. PMID: 25168388; PMCID: PMC4334820.

Hein R, Köster I, Bollschweiler E, Schubert I. Prevalence of inflammatory bowel disease: estimates for 2010 and trends in Germany from a large insurance- based regional cohort. Scand J Gastroenterol. 2014 Nov;49(11):1325-35. doi: 10.3109/00365521.2014.962605. Epub 2014 Sep 26. PMID: 25259808.

Khan S, Greco D, Michailidou K, […], Hein R, […],  Nevanlinna H. MicroRNA related polymorphisms and breast cancer risk. PLoS One. 2014 Nov 12;9(11):e109973. doi: 10.1371/journal.pone.0109973. PMID: 25390939; PMCID: PMC4229095.

Ahsan H, Halpern J, Kibriya MG, […], Hein R, […], Whittemore AS. A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):658-69. doi: 10.1158/1055-9965.EPI-13-0340. Epub 2014 Feb 3. PMID: 24493630; PMCID: PMC3990360.

Hein R, Flesch-Janys D, Dahmen N, Beckmann L, Lindström S, […], Chang-Claude J. A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication. Breast Cancer Res Treat. 2013 Apr;138(2):529-542. doi: 10.1007/s10549-013-2443-z. Epub 2013 Feb 20. PMID: 23423446; PMCID: PMC3781176.

Rudolph A, Hein R, Lindström S et al.; Breast Cancer Association Consortium. Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. Endocr Relat Cancer. 2013 Nov 4;20(6):875-87. doi: 10.1530/ERC-13-0349. PMID: 24080446; PMCID: PMC3863710.

Pearce CL, Rossing MA, Lee AW, […], Hein R, […], Kjaer SK; Ovarian Cancer Association Consortium. Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):880-90. doi: 10.1158/1055-9965.EPI-12-1030-T. Epub 2013 Mar 5. PMID: 23462924; PMCID: PMC3963289.

Garcia-Closas M, Couch FJ, Lindstrom S, […], Hein R, […], Kraft P. Genome- wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr;45(4):392-8, 398e1-2. doi: 10.1038/ng.2561. PMID: 23535733; PMCID: PMC3771695.

Bojesen SE, Pooley KA, Johnatty SE, […], Hein R, […], Dunning AM. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013 Apr;45(4):371-84, 384e1-2. doi: 10.1038/ng.2566. PMID: 23535731; PMCID: PMC3670748.

Michailidou K, Hall P, Gonzalez-Neira A, […], Hein R, […], Easton DF. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2. doi: 10.1038/ng.2563. PMID: 23535729; PMCID: PMC3771688.

Olsen CM, Nagle CM, Whiteman DC, […], Hein R, […], Webb PM; Ovarian Cancer Association Consortium. Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer. 2013 Mar 22;20(2):251-62. doi: 10.1530/ERC-12-0395. PMID: 23404857; PMCID: PMC3857135.

Nickels S, Truong T, Hein R, Stevens K, Buck K et al. Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet. 2013;9(3):e1003284. doi: 10.1371/journal.pgen.1003284. Epub 2013 Mar 27. PMID: 23544014; PMCID: PMC3609648.

Shen H, Fridley BL, Song H, […], Hein R, […], Pearce CL. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun. 2013;4:1628. doi: 10.1038/ncomms2629. PMID: 23535649; PMCID: PMC3848248.

Hein R, Maranian M, Hopper JL, Kapuscinski MK, Southey MC, […],Dunning AM. Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC). PLoS One. 2012;7(8):e42380. doi: 10.1371/journal.pone.0042380. Epub 2012 Aug 7.

Siddiq A, Couch FJ, Chen GK, […], Hein R, […], Vachon CM. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet. 2012 Dec 15;21(24):5373-84. doi: 10.1093/hmg/dds381. Epub 2012 Sep 13. PMID: 22976474; PMCID: PMC3510753.

Huhn S, Bevier M, Rudolph A, […], Hein R, […], Försti A. Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases. BMC Med Genet. 2012 Oct 5;13:94. doi: 10.1186/1471-2350-13-94. PMID: 23036011; PMCID: PMC3522999.

Lu Y, Chen X, Beesley J, […], Hein R, […], Chenevix-Trench G. Genome-wide association study for ovarian cancer susceptibility using pooled DNA. Twin Res Hum Genet. 2012 Oct;15(5):615-623. doi: 10.1017/thg.2012.38. Epub 2012 Jul 13. PMID: 22794196; PMCID: PMC3785301.

Rudolph A, Hein R, Hoffmeister M, Försti A, Hemminki K,et al. Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy. Int J Cancer. 2012 Sep 1;131(5):E841-8. doi: 10.1002/ijc.27428. Epub 2012 May 29. PMID: 22234881.

Lambrechts D, Truong T, Justenhoven C, […], Hein R, […], Brauch H. 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat. 2012 Jul;33(7):1123-32. doi: 10.1002/humu.22089. Epub 2012 Apr 30. PMID: 22461340; PMCID: PMC3370081.

Pearce CL, Templeman C, Rossing MA, […], Hein R, […], Berchuck A; Ovarian Cancer Association Consortium. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012 Apr;13(4):385-94. doi: 10.1016/S1470-2045(11)70404-1. Epub 2012 Feb 22. PMID: 22361336; PMCID: PMC3664011.

Schubert I, Hein R, Abbas S, Thürmann P. The frequency of prescription of immediate-release nifedipine for elderly patients in Germany: utilization analysis of a substance on the PRISCUS list of potentially inappropriate medications. Dtsch Arztebl Int. 2012 Mar;109(12):215-9. doi: 10.3238/arztebl.2012.0215. Epub 2012 Mar 23. PMID: 22532813; PMCID: PMC3329146.

Ghoussaini M, Fletcher O, Michailidou K, […], Hein R, […], Easton DF. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet. 2012 Jan 22;44(3):312-8. doi: 10.1038/ng.1049. PMID: 22267197; PMCID: PMC3653403.

Figueroa JD, Garcia-Closas M, Humphreys M, […], Hein R, […], Spurdle AB. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet. 2011 Dec 1;20(23):4693-706. doi: 10.1093/hmg/ddr368. Epub 2011 Aug 18. PMID: 21852249; PMCID: PMC3209823.

Haiman CA, Chen GK, Vachon CM, […], Hein R, […], Couch FJ. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011 Oct 30;43(12):1210-4. doi: 10.1038/ng.985. PMID: 22037553; PMCID: PMC3279120.

Milne RL, Lorenzo-Bermejo J, Burwinkel B, […], Hein R, […], Chenevix-Trench G. 7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium. J Med Genet. 2011 Oct;48(10):698-702. doi: 10.1136/jmedgenet-2011-100303. PMID: 21931171; PMCID: PMC3371608.

Stevens KN, Vachon CM, Lee AM, […], Hein R, […], Couch FJ. Common breast cancer

susceptibility loci are associated with triple-negative breast cancer. Cancer Res. 2011 Oct 1;71(19):6240-9. doi: 10.1158/0008-5472.CAN-11-1266. Epub 2011 Aug 15. PMID: 21844186; PMCID: PMC3327299.

Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, […], Easton DF. Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2222-31. doi: 10.1158/1055-9965.EPI-11-0569. Epub 2011 Jul 27. PMID: 21795498; PMCID: PMC4164116.

Seibold P, Hein R, Schmezer P, Hall P, Liu J et al. Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk. Int J Cancer. 2011 Sep 15;129(6):1467-76. doi: 10.1002/ijc.25761. Epub 2011 Jan 6. PMID: 21792883.

Broeks A, Schmidt MK, Sherman ME, […], Hein R, […], Garcia-Closas M. Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet. 2011 Aug 15;20(16):3289-303. doi: 10.1093/hmg/ddr228. Epub 2011 May 19. PMID: 21596841; PMCID: PMC3140824.