Regulation of misguided immune reactions: We are working on the pathophysiology of novel immunotherapeutic approaches for pathological immune reactions. For this, we are focusing on animal models of Graft-versus-host-disease (GvHD), a major complication after allogeneic bone marrow transplantation.
The role of CD4+ T cells in myocardial wound healing: While the role of innate immunity to wound healing after myocardial infarction (MI) is well established, little is known about the contribution of adaptive immunity, in particular CD4+ T cells, to this process.
Our research focus is on the functional characteristics of innate immune cells. We are specialized to investigate tolerogenic versus immunogenic dendritic cells and the origin, developmental signals and activation requirements of myeloid-derived suppressor cells. We use various immunological techniques that are applied in murine disease models of autoimmunity and infection.