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Deutsch Intern
Würzburg Institute of Systems Immunology

Host-microbial interactions (Gomez de Agüero Lab)

Mammalians harbor trillions of millions of microorganisms, including bacteria, fungi, protozoa, archaea and virus. Most of these microorganisms constituent the commensal microbiota, which provides to the host access to essential vitamins, energy, and pathogen exclusion. In addition, it is now largely accepted that mammalian immunity is both directly and indirectly profoundly stimulated by exposure to microbiota and/or their molecular metabolites. Recently, several studies have defined a critical window early in life for the microbiota to shape the immune system establishing tissue homeostasis. Indeed, we have demonstrated that the maternal microbiota, during the gestation, shape the offspring immunity to prepare the newborn for the challenges that occurs from birth. Therefore, the microbiota and in particular, the maternal microbiota, are candidates to largely shape the development of the immune system.

Our projects aim to investigate the role of the microbiota in the development of the immune system in early life and the consequences in the health of infants and long-term effect, in the adult life. Our laboratory focuses in the impact of the microbiota in the development of tissue barriers during the gestation and the neonatal life, and in the immune responses of these organs in the context of infections, inflammatory diseases and auto-immune diseases.

Uchimura Y., Fuhrer T., Hai Li,. Lawson M., Zimmermann M., Yilmaz B., Zindel J., Ronchi F., Sorribas M., Hapfelmeier S., Ganal-Vonarburg S., Gomez de Aguero M., McCoy KD., Sauer U., Macperson AJ. « Antibodies set boundaries limiting microbial metabolite penetration and the resultant mamalian host reponse » (Immunity, 2018, September)

Fabbiano S, Suárez-Zamorano N, Chevalier C, Lazarević V, Kieser S, Rigo D, Leo S, Veyrat-Durebex C, Gaïa N, Maresca M, Merkler D, Gomez de Agüero M, Macpherson A, Schrenzel J, Trajkovski M. « Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements » (Cell Metab, 2018, December)

Hacini-Rachinel F., Gomez de Agüero M., Kanjarawi R., Moro-Sibilot L., Le Luduec JB., Macari C., Boschetti G., Barbel E., Langella P., Dubois B., Kaiserlian D. « Intestinal dendritic cell licensing through TLR4 is required for oral tolerance in allergic contact dermatitis»  (J Allergy Clin Immunol, 2017 March)

Gomez de Agüero M.*, Ganal-Vonarburg S.*, Uchimira Y., Fuhrer T. Rupp S., Steinert A., Hapfelmeier S., Sauer U., McCoy KD.*, Macperson AJ.* « Neonatal innate immune development driven by the maternal microbiota» (*Equal contribution) (Science, 2016 March 18th, 351)

Gomez de Agüero M., Vocanson M., Hacini-Rachinel F., Taillardet M., Malissen B., Sparwasser Tim., Kaiserlian D. Dubois B. « Epidermal Langerhans cells protect to allergic contact dermatitis by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells » (J Clin Invest, 2012, 122(5))

Review articles:

Macpherson A.J, Gomez de Agüero M., Ganal-Vonarburg SC. “How nutrition and the maternal microbiota shape the neonatal immune system” (Nature Reviews Immunology, 2017 June)

Ganal-Vonarburg SC., Fuhrer T., Gomez de Agüero M. “Maternal microbiota and antibodies as advocates of neonatal health” (Gut Microbes, 2017 March, 1:1-7)

Mooser C, Gomez de Agüero M., Ganal-Vonarburg SC. “Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective” (Current Opinion in Microbiology, 2018, August)

Girard-Madoux M., Gomez de Agüero M., Ganal-Vonarburg S., Mooser C, Belz GT., Macperson AJ., Vivier E. « The immunological functions of the Appendix : An example of redundancy ? » (Sem. in Immunology, 2018 April)

SNF PZ00P3_168012: Role of maternal microbiota and aryl hydrocarbon receptor signalling in establishing neonatal skin homeostasis

Dr. Mercedes Gomez de Agüero

Junior Group Leader
Versbacher Str. 9
97078 Würzburg
Building: E6
Room: 457

Theresa Schmidt

Technical Assistant
Versbacher Str. 9
97078 Würzburg
Building: E6
Room: 464

Ludovica Timperi

PhD Student
Versbacher Str. 9
Würzburg 97078
Building: E6
Room: 456