Deutsch Intern
  • Immunology Systems immunology Gomez lab
Systems Immunology Würzburg

Host-microbial interactions (Gomez de Agüero Lab)

Mammalians harbor trillions of millions of microorganisms, including bacteria, fungi, protozoa, archaea and virus. Most of these microorganisms constituent the commensal microbiota, which provides to the host access to essential vitamins, energy, and pathogen exclusion. In addition, it is now largely accepted that mammalian immunity is both directly and indirectly profoundly stimulated by exposure to microbiota and/or their molecular metabolites. Recently, several studies have defined a critical window early in life for the microbiota to shape the immune system establishing tissue homeostasis. Indeed, we have demonstrated that the maternal microbiota, during the gestation, shape the offspring immunity to prepare the newborn for the challenges that occurs from birth. Therefore, the microbiota and in particular, the maternal microbiota, are candidates to largely shape the development of the immune system.

Our projects aim to investigate the role of the microbiota in the development of the immune system in early life and the consequences in the health of infants and long-term effect, in the adult life. Our laboratory focuses in the impact of the microbiota in the development of tissue barriers during the gestation and the neonatal life, and in the immune responses of these organs in the context of infections, inflammatory diseases and auto-immune diseases.

Gomez link pubmed: https://pubmed.ncbi.nlm.nih.gov

Selected Articles

  1. Resident macrophages acquire innate immune memory in staphylococcal skin infection. Feuerstein R, Forde AJ, Lohrmann F, Kolter J, Ramirez NJ, Zimmermann J, Gomez de Agüero M, Henneke P. Elife. 2020 Jul 8;9:e55602. doi: 10.7554/eLife.55602.
  2. Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity Pfister SP, Schären OP, Beldi L, Printz A, Notter MD, Mukherjee M, Li H, Limenitakis JP, Werren JP, Tandon D, Cuenca M, Hagemann S, Uster SS, Terrazos MA, Gomez de Agüero M, Schürch CM, Coelho FM, Curtiss R 3rd, Slack E, Balmer ML, Hapfelmeier S.. Nat Commun. 2020 Apr 24;11(1):1978. doi: 10.1038/s41467-020-15891-9.
  3. Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation. Lehmann FM, von Burg N, Ivanek R, Teufel C, Horvath E, Peter A, Turchinovich G, Staehli D, Eichlisberger T, Gomez de Agüero M, Coto-Llerena M, Prchal-Murphy M, Sexl V, Bentires-Alj M, Mueller C, Finke D. Nat Commun. 2020 Apr 14;11(1):1794. doi: 10.1038/s41467-020-15612-2.
  4. Neuronal programming by microbiota regulates intestinal physiology. Obata Y, Castaño Á, Boeing S, Bon-Frauches AC, Fung C, Fallesen T, de Agüero MG, Yilmaz B, Lopes R, Huseynova A, Horswell S, Maradana MR, Boesmans W, Vanden Berghe P, Murray AJ, Stockinger B, Macpherson AJ, Pachnis V. Nature. 2020 Feb;578(7794):284-289. doi: 10.1038/s41586-020-1975-8.
  5. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH. J Immunol. 2019 Jul 15;203(2):544-556. doi: 10.4049/jimmunol.1800938.
  6. Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response. Uchimura Y, Fuhrer T, Li H, Lawson MA, Zimmermann M, Yilmaz B, Zindel J, Ronchi F, Sorribas M, Hapfelmeier S, Ganal-Vonarburg SC, Gomez de Agüero M, McCoy KD, Sauer U, Macpherson AJ. Immunity. 2018 Sep 18;49(3):545-559.e5. doi: 10.1016/j.immuni.2018.08.004.
  7. Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements. Fabbiano S, Suárez-Zamorano N, Chevalier C, Lazarević V, Kieser S, Rigo D, Leo S, Veyrat-Durebex C, Gaïa N, Maresca M, Merkler D, Gomez de Agüero M, Macpherson A, Schrenzel J, Trajkovski M. Cell Metab. 2018 Dec 4;28(6):907-921.e7. doi: 10.1016/j.cmet.2018.08.005.
  8. Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis. Hacini-Rachinel F, Gomez de Agüero M, Kanjarawi R, Moro-Sibilot L, Le Luduec JB, Macari C, Boschetti G, Bardel E, Langella P, Dubois B, Kaiserlian D. J Allergy Clin Immunol. 2018 Jan;141(1):163-170. doi: 10.1016/j.jaci.2017.02.022. Epub 2017 Mar 22.
  9. The maternal microbiota drives early postnatal innate immune development.Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, McCoy KD, Macpherson AJ. Science. 2016 Mar 18;351(6279):1296-302. doi: 10.1126/science.aad2571.
  10. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. Gomez de Agüero M, Vocanson M, Hacini-Rachinel F, Taillardet M, Sparwasser T, Kissenpfennig A, Malissen B, Kaiserlian D, Dubois B. J Clin Invest. 2012 May;122(5):1700-11. doi: 10.1172/JCI59725.


Selected Review Articles


  1. Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective. Mooser C, Gomez de Agüero M, Ganal-Vonarburg SC. Curr Opin Microbiol. 2018 Aug;44:50-60. doi: 10.1016/j.mib.2018.07.007.
  2. The immunological functions of the Appendix: An example of redundancy? Girard-Madoux MJH, Gomez de Agüero M, Ganal-Vonarburg SC, Mooser C, Belz GT, Macpherson AJ, Vivier E. Semin Immunol. 2018 Apr;36:31-44. doi: 10.1016/j.smim.2018.02.005.
  3. How nutrition and the maternal microbiota shape the neonatal immune system. Macpherson AJ, de Agüero MG, Ganal-Vonarburg SC. Nat Rev Immunol. 2017 Aug;17(8):508-517. doi: 10.1038/nri.2017.58.
  4. Maternal microbiota and antibodies as advocates of neonatal health Ganal-Vonarburg SC, Fuhrer T, Gomez de Agüero M.. Gut Microbes. 2017 Sep 3;8(5):479-485. doi: 10.1080/19490976.2017.1299847.  Erratum for: Addendum to: Gomez de Aguero M.*, , Ganal-Vonarburg S.C.*, , Fuhrer T., , Rupp S., , Uchimura Y., , Li H., , Steinert A., , Heikenwalder M., , Hapfelmeier S., , Sauer U., , McCoy K.D., , Macpherson A. J. (2016). The maternal microbiota drives early postnatal innate immune development. Science 351, 1296-1302. *Co-first authors. PMID: 28296565; PMCID: PMC5628635.

SNF PZ00P3_168012: Role of maternal microbiota and aryl hydrocarbon receptor signalling in establishing neonatal skin homeostasis

Mariachiara Aloisi

PhD student / Gomez de Agüero Lab

Jessica Bohlender

Master student (AG Gomez)

Dr. Parul Chandorkar

Postdoc / Gomez de Agüero Lab
Photo of Parul Chandorkar WüSi Institute for Systems immunology Immunologie Würzburg

Louisa Channon

Research Assistant / Gomez de Agüero Lab

Dr. Mercedes Gomez de Agüero

Junior Group Leader
Photo of Mercedes Gomez de Agüero WüSi Institute Systems immunology Immunologie Würzburg

Muthita Khamwong

PhD student / Gomez de Agüero Lab

Dr. Janina Marissen

Rotating Clinician Scientist / Gomez de Agüero Lab
Photo of Janina Marissen WüSi Institute for Systems immunology Immunologie Würzburg

Dr. Aryan Rahimi Midani

Postdoc / Gomez de Agüero Lab

Lilith Reichert

Photo of Lilith Reichert WüSi Institute for Systems immunology Immunology Würzburg

Theresa Schmidt

Technician / Gomez de Agüero Lab
Photo of Theresa Schmidt WüSi Institute Systems immunology Immunologie Würzburg

Harini Varadharajan Vajjala

Technician / Gomez de Agüero Lab