piwik-script

Deutsch Intern
Würzburg Institute of Systems Immunology

Metabolism and Immune Cell Signalling (Vaeth Lab)

A major challenge for the immune system is the discrimination between ‘self’ tissue and ‘non-self’ antigens that are associated with pathogens or transformed cells. Immunological tolerance is the fine but flexible balance between effective destruction of infected or malignant cells and the protection of the body’s own healthy tissue. Dysregulation of this equilibrium can result in severe immunological pathologies ranging from immunodeficiency to autoimmunity.

Our laboratory investigates the control of different lymphocyte populations at the molecular level to understand their regulation during complex immune reactions. In addition to signal transduction (e.g. by Ca2+ ions) and the control of gene expression in immune cells (e.g. by transcription factors of the NFAT family), we are especially interested in the metabolic regulation of immune cells during infection and cancer. A deeper understanding of the regulatory circuits in different immune cells promises novel avenues for the development of advanced immunotherapies for the treatment of autoimmunity and cancer.

Väth link pubmed: https://pubmed.ncbi.nlm.nih.gov

Selected Articles

  1. Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization. Eckstein M, Vaeth M, Aulestia FJ, Costiniti V, Kassam SN, Bromage TG, Pedersen P, Issekutz T, Idaghdour Y, Moursi AM, Feske S, Lacruz RS. Sci Signal. 2019 Apr 23;12(578):eaav4663. doi: 10.1126/scisignal.aav4663.
  2. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels. Vaeth M, Wang YH, Eckstein M, Yang J, Silverman GJ, Lacruz RS, Kannan K, Feske S. Nat Commun. 2019 Mar 12;10(1):1183. doi: 10.1038/s41467-019-08959-8.
  3. Ion channelopathies of the immune system. Vaeth M, Feske S. Curr Opin Immunol. 2018 Jun;52:39-50. doi: 10.1016/j.coi.2018.03.021.
  4. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Vaeth M, Maus M, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, Cameron S, Turvey SE, Serfling E, Berberich-Siebelt F, Possemato R, Feske S. Immunity. 2017 Oct 17;47(4):664-679.e6. doi: 10.1016/j.immuni.2017.09.003.
  5. Store-operated Ca2+ entry controls ameloblast cell function and enamel development. Eckstein M, Vaeth M, Fornai C, Vinu M, Bromage TG, Nurbaeva MK, Sorge JL, Coelho PG, Idaghdour Y, Feske S, Lacruz RS. JCI Insight. 2017 Mar 23;2(6):e91166. doi: 10.1172/jci.insight.91166.
  6. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S. Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714.
  7. Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. Vaeth M, Bäuerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, Rosenwald A, Beilhack A, Berberich-Siebelt F. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1125-30. doi: 10.1073/pnas.1409290112.
  8. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. J Immunol. 2015 Aug 1;195(3):1202-17. doi: 10.4049/jimmunol.1403013.
  9. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. Vaeth M, Müller G, Stauss D, Dietz L, Klein-Hessling S, Serfling E, Lipp M, Berberich I, Berberich-Siebelt F. J Exp Med. 2014 Mar 10;211(3):545-61. doi: 10.1084/jem.20130604.
  10. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Müller MR, Serfling E, Sawitzki BS, Berberich-Siebelt F. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16258-63. doi: 10.1073/pnas.1203870109.
  11. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108.

 

Selected Review Articles

 

  1. Calcium regulation of T cell metabolism. Wang Y, Tao A, Vaeth M, Feske S. Curr Opin Physiol. 2020 Oct;17:207-223. doi: 10.1016/j.cophys.2020.07.016
  2. CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity. Vaeth M, Kahlfuss S, Feske S. Trends Immunol. 2020 Oct;41(10):878-901. doi: 10.1016/j.it.2020.06.012.
  3. Ion channelopathies of the immune system. Vaeth M, Feske S. Curr Opin Immunol. 2018 Jun;52:39-50. doi: 10.1016/j.coi.2018.03.021.
  4. NFAT control of immune function: New Frontiers for an Abiding Trooper. Vaeth M, Feske S. F1000Res. 2018 Mar 2;7:260. doi: 10.12688/f1000research.13426.1.

Miriam Eckstein

Technician / Väth Lab
Versbacher Str. 9
97078 Würzburg

Sophia Hochrein

PhD Student / Gasteiger Lab
Versbacher Str. 9
97078 Würzburg

Dr. Martin Väth

Junior Group Leader
Versbacher Str. 9
97078 Würzburg

Dr. Hao Wu

Postdoc / Väth Lab
Versbacher Str. 9
97078 Würzburg