A major challenge for the immune system is the discrimination between ‘self’ tissue and ‘non-self’ antigens that are associated with pathogens or transformed cells. Immunological tolerance is the fine but flexible balance between effective destruction of infected or malignant cells and the protection of the body’s own healthy tissue. Dysregulation of this equilibrium can result in severe immunological pathologies ranging from immunodeficiency to autoimmunity.
Our laboratory investigates the control of different lymphocyte populations at the molecular level to understand their regulation during complex immune reactions. In addition to signal transduction (e.g. by Ca2+ ions) and the control of gene expression in immune cells (e.g. by transcription factors of the NFAT family), we are especially interested in the metabolic regulation of immune cells during infection and cancer. A deeper understanding of the regulatory circuits in different immune cells promises novel avenues for the development of advanced immunotherapies for the treatment of autoimmunity and cancer.
Publikationen (Top 10):
1. Vaeth M, Maus M, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, et al. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity 2017, 47(4): 664-679 e666.
2. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, et al. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Nature communications 2017, 8: 14714.
3. Vaeth M, Eckstein M, Shaw PJ, Kozhaya L, Yang J, Berberich-Siebelt F, et al. Store-Operated Ca2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity. Immunity 2016.
4. Vaeth M, Bauerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, et al. Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity. Proc Natl Acad Sci U S A 2015, 112(4): 1125-1130.
5. Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, et al. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol 2015, 195(3): 1202-1217.
6. Vaeth M, Muller G, Stauss D, Dietz L, Klein-Hessling S, Serfling E, et al. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med 2014, 211(3): 545-561.
7. Vaeth M, Schliesser U, Muller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 2012, 109(40): 16258-16263.
8. Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, et al. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 2011, 108(6): 2480-2485.
9. Vaeth M, Feske S. Ion channelopathies of the immune system. Current opinion in immunology 2018, 52: 39-50.
10. Vaeth M, Feske S. NFAT control of immune function: New Frontiers for an Abiding Trooper. F1000Research 2018, 7: 260.