My research group focuses on how immune cells perceive their physical environment. Using single molecule, traction force as well as confocal microscopes on primary immune cells, we watch live how these cells react to different stiffnesses and how their migration and activation are influenced.
Central points of our research are:
- T cell mechanosensing in lymph nodes
- Role of actin conformation in T cell activation and mechanosensing
- Autoantibodies in autoimmune diseases