Deutsch Intern
  • Copyright: Max Planck Research Group for Systems Immunology
Systems Immunology Würzburg

Translational medicine (Lippert Lab)


My research group focuses on how immune cells perceive their physical environment. Using single molecule, traction force as well as confocal microscopes on primary immune cells, we watch live how these cells react to different stiffnesses and how their migration and activation are influenced.

Central points of our research are:

- T cell mechanosensing in lymph nodes

- Role of actin conformation in T cell activation and mechanosensing

- Autoantibodies in autoimmune diseases

Selected Articles

  • Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases, Anna H. Lippert, Christopher Paluch, Meike Gaglioni, Mai T. Vuong, James McColl, Edward Jenkins, Martin Fellermeyer, Joseph Clarke, Sumana Sharma, Sara Moreira da Silva, Billur Akkaya, Consuelo Anzilotti, Sara H. Morgan, Claire F. Jessup, Markus Körbel, Uzi Gileadi, Judith Leitner, Rachel Knox, Mami Chirifu, Jiandong Huo, Susan Yu, Nicole Ashman, Yuan Lui, Ian Wilkinson, Kathrine E. Attfield, Lars Fugger, Nathan J. Robertson, Christopher J. Lynch, Lynne Murray, Peter Steinberger, Ana Mafalda Santos, Steven F. Lee, Richard J. Cornall, David Klenerman, Simon J. Davis, Immunity 02/2024, DOI: 10.1016/j.immuni.2024.01.007
  • Imaging the TCR: New Approaches, new Insights, Adam Rochussen, Anna Lippert, Gillian Griffiths, Current opinion in Immunology 2023, DOI: 10.1016/j.coi.2023.102309
  • Trapping or Slowing the Diffusion of T-cell receptors at Close Contacts Initiates T-cell Signaling, Kevin Y Chen, Edward Jenkins, Markus Koerbel, Aleks Ponjavic, Anna Lippert, Mafalda Cunha Santos, Nicole Ashman, Jemma McBride, David Klenerman, Simon J. Davis, PNAS 2021, DOI: 10.1073/pnas.2024250118
  • Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions Anna H. Lippert*, Ivan B. Dimov, Alexander K. Winkel, Jane Humphrey, James McColl, Kevin Y. Chen, Ana Mafalda Santos, Edward Jenkins, Kristian Franze, Simon J. Davis, David Klenerman, Biophysical Journal 2021, DOI:
  • The costs of close contacts: Visualizing the energy landscape of cell contacts at the nanoscale A. H. Lippert, K. Kulenkampff, J. McColl, M. A. Santos, A. Ponjavic, Edward Jenkins, Jane Humphrey, Alexander Winkel, Kristian Franze, S. F. Lee, S. J. Davis, D. Klenerman, Biophysical Journal 2020, 118(6), 1261-1269, DOI: 10.1016/j.bpj.2020.01.019
  •  4D imaging reveals stage dependent random and directed cell motion during somite morphogenesis James McColl, Gi Fay Mok, Anna H Lippert, Aleks Ponjavic, Leila Muresan, Andrea E Munsterberg., Scientific Reports 2018, 8, 12644, DOI: 10.1038/s41598-018-31014-3
  • Fabrication of Scaffold-Based 3D Magnetic Nanowires for Domain Wall Applications Dedalo Sanz-Hernandez, Ruben F. Hamans, Johannes Osterrieth, Jung-Wei Liao, Luka Skoric, Jason D. Fowlkes, Philip D. Rack, Anna Lippert, Steven F. Lee, Reinoud Lavrijsen and Amalio Fernandez-Pacheco, Nanomaterials 2018, 8(7), 483, DOI:10.3390/nano8070483
  • Single-molecule light-sheet imaging of suspended T cells A. Ponjavic, J. McColl, A. Carr, A.M. Santos, K. Kulenkampff, A. Lippert , S. Davis, D. Klenerman, S. F. Lee, Biophysical Journal 2018, 114(9), 2200-2211, DOI:10.1016/j.bpj.2018.02.044
  • Single-molecule imaging of Wnt3A protein diffusion on living cell membranes Anna Lippert, Agnieszka A. Janeczek, Alexandre Fuerstenberg, Aleks Ponjavic, W.E. Moerner, Roel Nusse, Jill A. Helms, Nicholas D. Evans, and Steven F. Lee, Biophysical Journal 2017, 113(12), 2762-2767, DOI: 10.1016/j.bpj.2017.08.060
  • Mechanical plasticity of cells Navid Bonakdar, Richard Gerum, Michael Kuhn, Anna Lippert, Werner Schneider, Ben Fabry, Nature Materials 2016, 15, 1090-1094, Doi:10.1038/nmat4689
  • Compartmentalization and Transport in Synthetic Vesicles, Schmitt C, Lippert AH, Bonakdar N, Sandoghdar V and Voll LM Front. Bioeng. Biotechnol. 2016, 4(19), DOI: 10.3389/fbioe.2016.00019

Funding for Würzburg Biophysicist

Prof. Dr. Anna Lippert

Juniorprofessur für Translationale Medizin
Anna Lippert_WueSi_Systems immunology

Michael Kühlwein

HiWi / Lippert Lab