Lehrstuhl für Orthopädie


    • Evers M, Schreder M, Stühmer T, Jundt F, Ebert R, Hartmann TN, Altenbuchinger M, Rudelius M, Kuric M, Rindt WD, Steinbrunn T, Langer C, Heredia-Guerrero SC, Einsele H, Bargou RC, Rosenwald A, Leich E. (2023) Prognostic value of extracellular matrix gene mutations and expression in multiple myeloma. Blood Cancer J. doi: 10.1038/s41408-023-00817-7
    • Mut J, Altmann S, Reising S, Meißner-Weigl J, Driessen MD, Ebert R, Seibel J. (2023) SiaNAl can be efficiently incorporated in glycoproteins of human mesenchymal stromal cells by metabolic glycoengineering. ACS Biomater Sci Eng. Mar 22. doi: 10.1021/acsbiomaterials.2c01534
    • Kaltdorf M, Breitenbach T, Karl S, Fuchs M, Kessie DK, Psota E, Prelog M, Sarukhanyan E, Ebert R, Jakob F, Dandekar G, Naseem M, Liang C, Dandekar T. (2023) Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis. Sci Rep. 13(1):1855. doi: 10.1038/s41598-022-27098-7
    • Pattappa G, Markway BD, Docheva D, Johnstone B. Physioxic Culture of Chondrogenic Cells. Methods Mol Biol. 2023;2598:45-63. doi: 10.1007/978-1-0716-2839-3_5

    • Ebert R*, Weissenberger M*, Braun C, Wagenbrenner M, Herrmann M, Müller-Deubert S, Krug M, Jakob F, Rudert M. (2022) Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. J Orthop Res, 40:513–523. doi: 10.1002/jor.25041  *equal contribution
    • Brandl A, Solimando AG, Mokhtari Z, Tabares P, Medler J, Manz H, Da Via M, Croci GA, Kurzwart M, Thusek S, Schneider T, Ebert R, Jakob F, Einsele H, Beilhack A. (2022) Junctional Adhesion Molecule-C expression specifies a CD138low/neg multiple myeloma cell population in mice and men. Blood Adv, 6(7):2195-2206. doi: 10.1182/bloodadvances.2021004354
    • Wagenbrenner M, Poker K, Heinz T, Herrmann M, Horas K, Ebert R, Mayer-Wagner S, Holzapfel BM, Rudert M, Steinert AF, Weißenberger M. (2022) Mesenchymal stromal cells (MSCs) isolated from various tissues of the human arthritic knee joint possess similar multipotent differentiation potential. Appl Sci, 12(4), 2239; doi: 10.3390/app12042239
    • Horas K, Abraham M, Ebert R, Weissenberger M, Maier GS, Jakob F, Rosenwald A, Rudert M (2022) Vitamin D receptor expression is significantly decreased in bone metastases compared to matched primary breast cancer tumours, Cancer Investigation, Nov 4:1-11. doi: 10.1080/07357907.2022.2142604
    • Seiler J, Ebert R, Rudert M, Herrmann M, Leich E, Weißenberger M, Horas K. (2022) Bone metastases of diverse primary origin frequently express the VDR (vitamin D receptor) and CYP24A1, J Clin Med. Nov 3;11(21):6537. doi: 10.3390/jcm11216537
    • Walter N, Stich T, Docheva D, Alt V, Rupp M. Evolution of implants and advancements for osseointegration: A narrative review. Injury. 2022 Nov;53 Suppl 3:S69-S73. doi: 10.1016/j.injury.2022.05.057
    • Krenek T, Stich T, Docheva D, Mikysek P, Kostejn M, Jandova V, Fajga rR, Pola M, Kovarik T, Moskal D, Forejtova J, Pola J. Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium. Surface & Coat Tech. 2022 Oct 15;447:128820. doi: 10.1016/j.surfcoat.2022.128820
    • Schulze-Tanzil GG, Delgado-Calcares M, Stange R, Wildemann B, Docheva D. Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon. Bone Joint Res. 2022 Aug;11(8):561-574. doi: 10.1302/2046-3758.118.BJR-2021-0576.R1
    • Wang G, Alagboso FI, Walter N, Baertl S, Brochhausen C, Docheva D, Rupp M, Alt V. Bone regeneration after marginal bone resection in two-stage treatment of chronic long bone infection - a combined histopathological and clinical pilot study. Injury. 2022 Oct;53(10):3446-3457. doi: 10.1016/j.injury.2022.07.008. Epub 2022 Jul 9.
    • Calejo I, Labrador-Rached CJ, Gomez-Florit M, Docheva D, Reis RL, Domingues RMA, Gomes ME. Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology. Adv Healthc Mater. 2022 Aug;11(15):e2102863. doi: 10.1002/adhm.202102863. Epub 2022 Jun 12
    • Alagboso FI, Mannala GK, Walter N, Docheva D, Brochhausen C, Alt V, Rupp M. Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection. Bone Joint Res. 2022 May;11(5):327-341. doi: 10.1302/2046-3758.115.BJR-2021-0395.R1
    • Angele P, Docheva D, Pattappa G, Zellner J. Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach. Knee Surg Sports Traumatol Arthrosc. 2022 Apr;30(4):1138-1150. doi: 10.1007/s00167-021-06497-9. Epub 2021 Mar 5
    • Mannala GK, Rupp M, Walter N, Brunotte M, Alagboso F, Docheva D, Brochhausen C, Alt V. Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus. Eur Cell Mater. 2022 Feb 24;43:66-78. doi: 10.22203/eCM.v043a07
    • Pattappa G, Reischl F, Jahns J, Schewior R, Lang S, Zellner J, Johnstone B, Docheva D, Angele P. Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia. Front Bioeng Biotechnol. 2022 Jan 28;9:789621. doi: 10.3389/fbioe.2021.789621. eCollection 2021

    • Stich T, Alagboso F, Křenek T, Kovářík T, Alt V, Docheva D. Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo. Bioeng Transl Med. 2021 Jul 12;7(1):e10239. doi: 10.1002/btm2.10239. eCollection 2022 Jan.
    • Delgado Caceres M, Angerpointner K, Galler M, Lin D, Michel PA, Brochhausen C, Lu X, Varadarajan AR, Warfsmann J, Stange R, Alt V, Pfeifer CG, Docheva D. Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.
      Cell Death Dis. 2021 Nov 5;12(11):1049. doi: 10.1038/s41419-021-04298-z.
    • Krenek T, Jandova V, Kovarik T, Pola M, Moskal D, Pola J, Stich T, Docheva D, Fajgar R, Mikysek P, Kolska Z. Micro/nano-structured titanium surfaces modified by NaOH-CaCl2-heat-water treatment: Biomimetic calcium phosphate deposition and hMSCs behavior. Mat Chem Phys. 2021 Nov 1;272:124896. doi: 10.1016/j.matchemphys.2021.124896.
    • Krenek T, Pola J, Docheva D, Stich T, Fajgar R, Kovarik T, Pola M, Martan J, Moskal D, Jandova V, Kupcik J, Mikysek P. Porous micro/nano structured oxidic titanium surface decorated with silicon monoxide. Surface Interfaces. 2021 Oct;26:101304. doi: 10.1016/j.surfin.2021.101304.
    • Zhang J, Geiger Y, Sotier F, Djordjevic S, Docheva D, Sudhop S, Clausen-Schaumann H, Huber HP. Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations. Micromachines (Basel). 2021 Sep 29;12(10):1172. doi: 10.3390/mi12101172.
    • Di Pauli von Treuheim T, Torre OM, Ferreri ED, Nasser P, Abbondandolo A, Delgado Caceres M, Lin D, Docheva D, Iatridis JC. Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration. Cartilage. 2021 Dec;13(2_suppl):604S-614S. doi: 10.1177/19476035211029696.
    • Chu J, Pieles O, Pfeifer CG, Alt V, Morsczeck C, Docheva D.Dental follicle cell differentiation towards periodontal ligament-like tissue in a self-assembly three-dimensional organoid model. Eur Cell Mater. 2021 Jul 12;42:20-33. doi: 10.22203/eCM.v042a02.
    • Madry H, Grässel S, Nöth U, Relja B, Bernstein A, Docheva D, Kauther MD, Katthagen JC, Bader R, van Griensven M, Wirtz DC, Raschke MJ, Huber-Lang M. The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus? Eur J Med Res. 2021 Jun 14;26(1):56. doi: 10.1186/s40001-021-00521-x.
    • Zhang J, Byers P, Erben A, Frank C, Schulte-Spechtel L, Heymann M, Docheva D, Huber HP, Sudhop S, Clausen-Schaumann H. Single Cell Bioprinting with Ultrashort Laser Pulses. Adv Funct Mat. 2021 May; 31(19):2100066. doi: 10.1002/adfm.202100066.
    • An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells.
      Xu Y , Yin H , Chu J , Eglin D , Serra T , Docheva D . Biomater Sci. 2021 Feb 21;9(4):1237-1245. doi: 10.1039/d0bm01127d. Epub 2021 Feb 12.
    • Xu Y, Yin H, Chu J, Eglin D, Serra T, Docheva D. An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells. Biomater Sci. 2021 Feb 21;9(4):1237-1245. doi: 10.1039/d0bm01127d. Epub 2021 Feb 12.
    • Shirley AJ., Schweeberg S., Waag T., Peindl M., Dandekar G., Walles H., Jakob F., Krueger A., Ebert R. (2021) The influence of differently functionalized nanodiamonds on proliferation, apoptosis and EMT/MET phenomena in 2D and 3D tumor cell cultures, J Mater Chem B, 9, 9395-9405.
    • Altmann S., Mut J., Wolf N., Meißner-Weigl J., Rudert M., Jakob F., Gutmann M., Lühmann T., Seibel J., Ebert R. (2021) Metabolic glycoengineering in hMSC-TERT cells as a model for skeletal precursors by using modified azide/alkyne mono-saccharides. Int J Mol Sci. 22(6), 2820. doi:10.3390/ijms22062820
    • Xu Y, Yin H, Chu J, Eglin D, Serra T, Docheva D. An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells. Biomater Sci. 2021 Feb 21;9(4):1237-1245. doi: 10.1039/d0bm01127d. Epub 2021 Feb 12.