Identification and metabolic profiling of bone marrow adipose tissue progenitors

Annika Schiminski, Christoph Kölbl, Bianca Schlierf, Marietta Herrmann, Drenka Trivanovic
 

Unlike extramedullary adipose tissue, bone marrow adipose tissue (BMAT) increases upon malnutrition, hematologic neoplasms and bone disease development. We investigate whether different microenvironmental cues might impose the specific functions of BMAT cell distinct to peripheral fat. The goal of the project is to identify human BMAT progenitors, investigating relations of their adipogenic commitment and programs with mitochondrial network, bioenergetic profile and epigenetic landscape as an interface between metabolism and the gene expression. These novel insights into BMAT physiology as an important marrow stem cell niche component will bring potential to modulate or target BMAT for the benefit of human health.

The project is funded by a grant of the Schering Stiftung and the Fritz Thyssen Foundation “Young Investigator Fund for Innovative Research Ideas”.