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    Musculoskeletal Center Wuerzburg

    IZKF News

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    November 2021

    Marietta Herrmann awarded with the TERMIS-EU Robert Brown Early Career Principle Investigator Award

    These were very amazing news at the end of the TERMIS meeting! Marietta`s early career achievements were honored with this precious award during the closing ceremony of the conference. This is for sure a reflection of all the great students, colleagues, collaborators and mentors along the way!

    November 2021

    TERMIS World Conference 2021 – back to the virtual world

    Unfortunately, we had to move back to the virtual world for this year`s TERMIS meeting. Although networking was difficult this way, the conference was packed with amazing science. Our group contributed with a presentation of Rita Pereira!

    November 2021

    3. MuSkITYR Symposium in Göttingen!

    The MuSkITYRs are a network for young translational researchers, where Marietta Herrmann acts as one of the speakers since 2019. Luckily, this year we could meet again for a face-to-face symposium. For the group this was associated with many first-time experiences. It was the first conference for Jovana Ilic, Magdalena Stöckl and Annika Schiminski as well as their first presentations in real life! Our conclusion in brief, a great job by everyone, an amazing meeting with great science and plenty networking opportunities!

    October 2021

    Marietta Herrmann`s habilitation wins the “AFOR Wissenschaftspreis 2021”

    The cumulative habilitation of Marietta focused on the regenerative mechanisms in musculoskeletal tissues and was awarded by the Association for Orthopedic Research (AFOR Stiftung). The ceremony will take next year in February during the annual meeting of the society in Pontresina, Switzerland.

    October 2021

    DKOU 2021 takes place in Berlin!

    Taking advantage of a still more or less stable pandemic situation, we could attend the annual DKOU conference in Berlin. Noah Volkmann presented the results of his MD thesis and did a great job at his first ever conference presentation.

    September 2021

    EORS Conference in Rome – finally a “real-life” conference again

    This year’s EORS conference took place in the beautiful city of Rome. Next to great science, where Marietta Herrmann contributed a talk on “Platelet-released factors induce an immune regulatory signature in bone marrow mesenchymal stromal cells”, it was really nice to meet old and new colleagues, collaborators and friends!

    September 2021

    Katharina Marnet is joining the group!

    Katharina will perform her PhD thesis on our DFG funded project on Primary Failure of Eruption (PFE) and investigate the molecular consequences of PTH1-receptor mutations in cells of the periodontal ligament. Read more here...

    August 2021

    New publication in Materials!

    Our paper entitled “Modeling of the Human Bone Environment: Mechanical Stimuli GuideMesenchymal Stem Cell–ExtracellularMatrix Interactions” with Rita Pereira as first author has been accepted for publication in the special issue “Bone regeneration materials”.  Read more here: doi.org/10.3390/ma14164431

    August 2021

    Sofia Paulus defended her thesis!

    Dentist Sofia Paulus successfully defended her MD thesis on the establishment of alkaline phosphatase deficient odontogenic cell lines using CRISPR/Cas9 gene editing techniques.

    Congratulations Miss Dr. med. Sofia Paulus!

    August 2021

    Sebastian Häusner is joining the group!

    We welcome Sebastian as a new PhD student in the group. He will work on the newly funded RIABONE project.

    July 2021

    BMBF project kick-off

    We are excited about the funding of a new collaborative project within the call WBC2019 dedicated to support research projects between Germany and Western Balkan States. The research consortium with the acronym RIABONE, coordinated by Marietta Herrmann is aiming to develop optimized bone autografts. Project partners are Prof. Torsten Blunk (Würzburg), Prof. Aleksandra Jauković, Prof. Dusko Spasovski, Prof. Petar Milosavljević (all Belgrade) and the industry partner Osartis.

    July 2021

    It is never too late to celebrate….

    The last months have been very successful and finally we were able to meet and celebrate the acquired fundings and published papers! It was a nice evening with former and future students!

    May 2021

    Very successful ECTS conference

    Again the Covid-19 pandemic prevented a face-to-face meeting. Still we had a very successful virtual meeting with three oral presentations. Congratulations to Drenka Trivanović for the following contributions:

    “New Insights Into Cells of Human Bone Marrow Adipose Tissue”

    “Acetabular and Femoral Bone Marrow in Patients with Hip Osteoarthrosis: Cellular Landscape of Immune and Stromal Compartments”

    “Extramedullary erythropoiesis is activated during hematoma phase of bone healing in mice”

    May 2021

    New article on “Networks for Young Musculoskeletal Researchers”

    This new publication in the journal Osteologie provides an overview on networking opportunities for young scientists in the musculoskeletal field. Coordinated by Marietta Herrmann the article was a joint project between members of: MuSkITYR (www.muskityr.com), Junges Forum O und U (www.jf-ou.de/startseite/) and AGA-Studenten (www.aga-online.ch/ausbildung/studenten/).  DOI 10.1055/a-1373-9297

    March 2021

    Virtual Osteology Conference 2021

    We actively participated in this year’s Osteology conference. Marietta Herrmann co-chaired the junior research session where Sofia Paulus delivered a presentation with the title: “Establishment of an alkaline phosphatase deficient odontogenous cell line to analyze dental aspects of hypophosphatasia”. Congratulations to Sofia for her first ever conference presentation!

    March 2021

    New students are joining the group – we welcome Annika Schiminski, Magdalena Stöckl and Christoph Kölbl!

    Annika is starting her MD thesis where she will characterize progenitor cells in bone marrow adipose tissue. The MD thesis of Magdalena will focus on survival mechanisms of MSC in inflammatory environments. Christoph will perform his Master thesis in our group and focus on the development of 3D co-culture models of MSC and Multiple Myeloma cells.

    February 2021

    Paper accepted!

    We are very happy that our collaborative work with Gloria Belén Ramírez-Rodríguez from Spain has been accepted for publication. Congratulations to Rita Pereira for her shared first authorship! Please check out our paper "Biomimetic Mineralization Promotes Viability and Differentiation of Human Mesenchymal Stem Cells in a Perfusion Bioreactor" here: doi.org/10.3390/ijms22031447

    January 2021

    Jana Schiffmaier is joining our group.

    Jana will do her MD thesis and investigate phenotypic alterations in cell lines with mutations in the ALPL gene encoding the Tissue Nonspecific Alkaline Phosphatase (TNAP) that serve as a model system for the rare disease hypophosphatasia.

    January 2021

    Our new review article on “Extracellular Vesicles in Muskuloskeletal Pathologies and Regeneration” is out!

    This new review was the result of collaborative work with other partners in a research consortium on extracellular vesicles (EVs) and their role in bone and cartilage pathologies. You will find a very comprehensive overview on EVs:


    December 2020

    DFG project on molecular mechanisms in PFE approved – PhD Student Wanted!

    In this project will focus on unravelling molecular mechanisms of the rare disease Primary Failure of Eruption (PFE), which is characterized by incomplete tooth eruption and associated with mutations in the parathyroid hormone receptor (PTH1R). The aim of the collaborative project with the orthodontic department (Prof. Martin Eigenthaler) is to apply genome editing strategies, such as CRISPR/Cas9, to generate transgenic cell lines to investigate functional consequences of PTH1R deficiency and to test potential novel therapeutic strategies. We can`t wait to get started!

    December 2020

    Marietta Herrmann successfully finished her habilitation!

    November 2020

    Drenka Trivanović receives funding from Fritz Thyssen Stiftung!

    In frame of the “boost your research” program Drenka acquired funding for her work on bone marrow adipose tissue progenitors. We are very happy for this support!

    October 2020

    ECTS 2020 Live Prime Time

    Although it is not the same as a real face to face meeting, we were very happy to attend the virtual ECTS congress, full with brilliant science! We contributed a poster on the cellular dynamics during the hematoma phase of bone healing presented by Drenka Trivanović. Moreover, we were happy to participate in the fund raising event to support FOP (Fibrodysplasia ossificans progressive) France.

    August 2020

    Rita Pereira receives ON/EORS Education Grant for the attendance of the virtual EORS congress!

    We are happy to announce that Rita received a grant covering the registration fee for this year’s virtual conference of the European Orthopedic Research Society. Rita will contribute a poster presentation and is looking forward to an interesting meeting.

    August 2020

    Jovana Ilic arrived in Germany!

    After months of waiting for her visa, Jovana finally could join our group and start her PhD work in the lab. Her thesis is supported by a fellowship from the Bavarian Research Alliance and will focus on interactions between MSC and multiple myeloma. Read more here

    July 2020

    Marietta Herrmann receives funding from the Max Buchner Forschungsstiftung!

    We are very happy about the support of a collaborative research project with the Department of Tissue Engineering and Regenerative Medicine (TERM)
    on “A modular fluid flow bioreactor system to investigate the role of oxygen tension in tumor invasion and metastasis".

    June 2020

    Kim Koschitzki defended her MD thesis!

    As first student in the group, Kim successfully completed her MD thesis entitled “Evaluation of preclinical animal models in bone tissue engineering and their success in clinical translation”. Congratulations!

    June 2020

    New team members!

    Slowly restarting our regular lab work, we are joined by new team members: Bianca Schlierf and Andrea Knorz will support the group as technical assistants, while Mert Ergin, enrolled in the Biofabrictaion Master program at University Bayreuth will perform his thesis with us.

    April 2020

    Marietta Herrmann takes the turn as co-chair of the Musculoskeletal Center Würzburg (MCW).

    Together with Prof. Torsten Blunk (Department of Trauma-, Hand-, Plastic- and Reconstructive Surgery), Marietta is following the long-term speaker Prof. Franz Jakob as speaker of the MCW.

    April 2020

    Check out our new publication:

    Pereira AR, Rudert M, Herrmann M. Decellularized human bone as a 3D model to study skeletal progenitor cells in a natural environment. Methods Cell Biol. 2020;157:123-141. doi: 10.1016/bs.mcb.2019.11.018. Epub 2019 Dec 31.

    April 2020

    We are happy to have contributed to this great paper:

    Melms H, Herrmann M, Förstner K, Bharti R, Schneider D, Mentrup B, Rudert M, Schlagenhauf U, Jakob F, Graser S. Novel molecular cues for dental defects in hypophosphatasia. Exp Cell Res. 2020 Apr 22:112026. doi: 10.1016/j.yexcr.2020.112026.

    March 2020

    Noah Volkmann is joining our group.

    Supported by a GSLS fellowship, Noah started to work on his MD thesis on the role of extracellular vesicles in promoting the immunomodulatory functions of MSC in bone healing. Read more here

    March 2020

    Check out our new review article:

    Herrmann M, Engelke K, Ebert R, Müller-Deubert S, Rudert M, Ziouti F, Jundt F, Felsenberg D, Jakob F. Interactions between Muscle and Bone—Where Physics Meets Biology, Biomolecules, 2020

    February 2020

    Sofia Paulus starts her MD thesis.

    After recently finishing her degree in dentistry at University in Heidelberg, Sofia is joining our lab working on dental aspects of the rare disease hypophosphatasia. Read more here

    February 2020

    Finally arrived in our own lab!

    Having improvised all the last years, we now finally settled in our own lab! What a relief!

    December 2019

    Technical advances

    We just received our new flow cytometer, an Attune NxT Cytometer with 4 laser. Having our own flow cytometer also means much less commuting to other facilities!

    December 2019

    PhD fellowship by Bayerische Forschungsstiftung for Jovana Ilić

    We are happy to announce that our application for a PhD fellowship was approved. Now we are looking forward to welcome PhD student Jovana Ilić from Belgrade, starting in March next year to work on a project entitled “Wechselspiel zwischen Seneszenz und Stammzelleigenschaften im Multiplen Myelom und im Stroma des Wirts – Implikationen für Therapie und Diagnostik” in collaboration with the ForTiTher consortium.

    December 2019

    1st MuSkITYR Symposium in Günzburg

    Marietta Herrmann led the organization of the first symposium of the MuSkITYRs.

    November 2019

    Knochen, Muskeln, Gelenke – Update 2019 Berlin

    MD student Janek Harder gave his first conference presentation with the title: “Comparison of cellular characteristics in bone marrow from acetabulum and proximal femur in patients with coxarthrosis”. He also won a travel fellowship!

    October 2019

    DKOU 2019 – Berlin

    One month later, we again visited Berlin, where Drenka Trivanović contributed a talk with the title “Immune regulatory and stem cell functions of human bone marrow mesenchymal stromal cells exposed to hematoma factors in vitro”. We also took the chance to meet up with members of the MuSkITYR network.

    September 2019

    GSCN 2019 - Berlin

    Drenka Trivanović and Marietta Herrmann joined the annual conference of the German Stem Cell Network in Berlin, where Drenka presented her work “Coordinated activation of mouse mesenchymal and hematopoietic progenitors in the early stage of bone healing” on a poster.

    September 2019

    KCOS 2019 – Seoul

    Marietta Herrmann was invited as a representative of the ECTS Academy to give a lecture on “Mesenchymal Stem Cells in Orthopedic Diseases” at the annual Korean Congress Osteoporosis and Spine.

    July 2019

    Regeneration Research Symposium

    We were delighted to participate with a keynote lecture given by Marietta Herrmann in an awesome symposium on Regeneration Research in Würzburg which was followed by the official opening of the Bernhard-Heine-Center for Locomotion Research by the Bavarian minister of science Bernd Sibler.

    July 2019

    Best Graphical Abstract Award

    Our paper “Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro” won the eCM best graphical abstract January-June 2019 award!  

    27. -31.05.2019

    TERMIS 2019 in Rhodes

    Rita Pereira and Marietta Herrmann joined the EU-Chapter Meeting of TERMIS and Rita delivered a presentation on her work “A human bone-derived 3D scaffold for studying MSC interactions within the skeletal niche”.


    ECTS 2019 in Budapest

    Marietta Herrmann took part in this year`s annual meeting of the ECTS. Besides her involvement in the activities of the ECTS Academy, Marietta introduced the MuSkITYR network in the Next Generation Synergy Session and the group contributed a poster presentation.

    May 2019

    Exciting times for the group, new team members - new rooms

    After having been guests in the laboratories of the Orthopedic Center for Musculoskeltal Research for the past 2 years (a big thank you to the group for their hospitality), we have now moved to new rooms, where we closely collaborate with the Chair for Tissue Engineering and Regenerative Medicine (TERM), also here a big thank you for the warm welcome! At the same time 3 new team members started their theses in the group. Welcome to Janek Harder (MD Student), Jasmin Batani (B.Sc. Student) and Alexandra Maag (B.Sc. Student)!

    May 2019

    Marietta Herrmann elected as chair of the MuSkiTYR, www.MuSkITYR.com, @MuSkITYR

    One year after founding, the MuSkiTYR (MusculoSkeletal Interdisciplinary Translational Young Researchers) voted for new chair persons to take the lead in further shaping this young organization. Together with Felix Schmidt (Hamburg, co-chair), Marietta Herrmann will now take lead in running the network and organizing their acitivities.


    Poster Price for the group @Osteologie 2019 in Frankfurt

    At the annual Osteologie meeting we won the DVO Poster Price for our collaborative work with the AO Foundation Research Institut Davos. We are very grateful for this award and the great feedback!
    Title: Evaluation of Preclinical Models for Testing of Bone Tissue Engineered Constructs - Need for Optimization
    Authors: Stephan Zeiter, Kim Koschitzki, Mauro Alini, Maximilian Rudert, Marietta Herrmann


    Poster Price for the group @DKOU 2018 in Berlin

    MD student Maximilian Leucht (kindly supported by a student travel fellowship from DKOU) and Marietta Herrmann attended the annual DKOU meeting. As highlight of a successful meeting at the interface of science and clinics in Orthopedics & Trauma we were awarded a price for the best experimental poster! A great reward for great teamwork of the whole group!


    External Audit IZKF Würzburg

    Drenka Trivanović and Rita Pereira presented the research focus of the group during the external audit of the IZKF.


    EUREKA! 2018

    Rita Pereira did not only present her work, but was also part of the organization committee of the international symposium of the Graduate School of Life Sciences in Würzburg.


    Future Investigators of Regenerative Medicine (FIRM) Symposium

    Rita Pereira joined this great symposium organized by young researchers in Girona, Spain and presented her work “Natural-derived in vitro models to study the physical-chemical dynamics of bone healing” as oral and poster presentation.


    Annual Meeting of the German Stem Cell Network (GSCN)

    Drenka Trivanović and Marietta Herrmann attended this year’s meeting of the GSCN in Heidelberg with lots of brilliant science. Drenka presented a poster with the title “Hematoma components orchestrate immunomodulatory effects of human bone marrow mesenchymal stromal cells”.


    Travel grant for Drenka Trivanović!

    We are happy to announce that Drenka Trivanović received a travel grant from Boehringer Ingelheim Fonds to support her training in in vivo methods at the AO Research Institute Davos, Switzerland.


    Our group attended this year`s IZKF Retreat at lovely Kloster Banz. Next to plenty of networking opportunities with other IZKF members, we contributed a poster entitled “Mesenchymal stromal cells in in 3D culture systems: Insights into immunomodulatory activities” presented by Drenka Trivanović.


    During this year`s ECTS conference Marietta Herrmann was introduced as a new member of the ECTS Academy

    The ECTS Academy has be founded as a daughter society of the ECTS. The concept follows the model of interdisciplinary Young Academies: young researchers self-organise their society to foster personal contact and networking among the most talented young scientists. To learn more about the activities of the Academy follow us on twitter @AcademyEcts.


    The first abstract from our group was accepted for poster presentation at this year’s DKOU in Berlin (23.10.-26.10.2018)

    Title: The bone marrow microenvironment in patients undergoing hip endoprosthesis surgery due to coxarthrosis or femoral neck necrosis
    Authors: Marietta Herrmann (presenting), Boris Holzapfel, Theresa Kreuzahler, Maximilian Rudert, Drenka Trivanović


    Maximilian Leucht joined our group as MD student. His thesis will focus on the bone marrow microenvironment related to degenerative diseases of the femoral neck.


    Our group is in the spotlight of the recent IZKF Newsletter.