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Intern
Mildred-Scheel-Nachwuchszentrum

PhD student position - Riedel Group

Applications are invited for two PhD student positions in the group of Dr Angela Riedel (Metastasis, Metabolism and the Microenvironment)

The group is interested in the involvement of the tumor-draining lymph node in metastatic disease and tumour immune evasion. A main goal is to characterize the cellular cross-talk between tumour cells, cells of the immune system and the lymph node stroma.

Project a) Metabolites can play a major role in these processes and although it is well known that tumour cell transformation is accompanied by alterations of cellular metabolism to facilitate growth and proliferation, little is known about how this transformation impacts the cells of the microenvironment and cellular cross-talk. Within this project, the candidate will characterize the metabolic composition of metastatic niches and the epigenetic reprogramming associated with it. The main goal will be to identify the requirements of niche-reprogramming for a successful metastatic colonization.

Project b) Myeloid cells play a big role in tumor progression and the metastatic niche. Within this project, we want to characterize the different myeloid cell subsets at the primary tumor site and draining lymph node also during immune-checkpoint inhibition.

We are looking for highly motivated candidates that have an interest in combining wet lab and computational analysis. Prior knowledge of bioinformatics analysis (e.g., R, Python) is advantageous but not obligatory. For more information on the group click here

Projects start in July 2023 (an earlier or later start can be negotiated).
Applicants will be expected to have an excellent graduate degree in biology, biomedicine, biochemistry, computational biology, bioinformatics, or related discipline, sound knowledge and interest in cell and tumour biology, strong lab skills and a good command of the English language.

Applications can be submitted until June 5th, 2023.

We offer:

The centre is located at the Institute for Virology and Immunobiology at the University of Würzburg with fully equipped and modern laboratories, state-of-the-art technology, competitive funding and access to core facilities.

  • Full-time appointment for 3-years, salary (TV-L E13, 65%), fixed-term, extension possible,
  • Enrolment in the Graduate School of Life Science with broad research and skills training,
  • Close collaborations with the Comprehensive Cancer Centre, the University Hospital, the Max Planck Institute for Systems Immunology and the Biocentre in Würzburg,
  • Würzburg is a thriving place with local recreation areas and student-friendly vibes.

We welcome applications from suitably qualified people regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. Working language is English, knowledge of the German language can be beneficial, but is not required.

If you would like to hear more about the projects, please get in touch with the group leaders.

Please send applications including

  • a cover letter (with a statement of motivation),
  • curriculum vitae,
  • relevant degree certificates and academic transcripts,
  • contact details of 2 independent references (one of the referees should be the Master’s thesis supervisor)

as a single PDF file via email to phd-applications@msnz-wuerzburg.de