Jana Schiffmaier is joining our group.
Jana will do her MD thesis and investigate phenotypic alterations in cell lines with mutations in the ALPL gene encoding the Tissue Nonspecific Alkaline Phosphatase (TNAP) that serve as a model system for the rare disease hypophosphatasia.
Our new review article on “Extracellular Vesicles in Muskuloskeletal Pathologies and Regeneration” is out!
This new review was the result of collaborative work with other partners in a research consortium on extracellular vesicles (EVs) and their role in bone and cartilage pathologies. You will find a very comprehensive overview on EVs:
DFG project on molecular mechanisms in PFE approved – PhD Student Wanted!
In this project will focus on unravelling molecular mechanisms of the rare disease Primary Failure of Eruption (PFE), which is characterized by incomplete tooth eruption and associated with mutations in the parathyroid hormone receptor (PTH1R). The aim of the collaborative project with the orthodontic department (Prof. Martin Eigenthaler) is to apply genome editing strategies, such as CRISPR/Cas9, to generate transgenic cell lines to investigate functional consequences of PTH1R deficiency and to test potential novel therapeutic strategies. We can`t wait to get started!
Drenka Trivanović receives funding from Fritz Thyssen Stiftung!
In frame of the “boost your research” program Drenka acquired funding for her work on bone marrow adipose tissue progenitors. We are very happy for this support!
ECTS 2020 Live Prime Time
Although it is not the same as a real face to face meeting, we were very happy to attend the virtual ECTS congress, full with brilliant science! We contributed a poster on the cellular dynamics during the hematoma phase of bone healing presented by Drenka Trivanović. Moreover, we were happy to participate in the fund raising event to support FOP (Fibrodysplasia ossificans progressive) France.
Rita Pereira receives ON/EORS Education Grant for the attendance of the virtual EORS congress!
We are happy to announce that Rita received a grant covering the registration fee for this year’s virtual conference of the European Orthopedic Research Society. Rita will contribute a poster presentation and is looking forward to an interesting meeting.
Jovana Ilic arrived in Germany!
After months of waiting for her visa, Jovana finally could join our group and start her PhD work in the lab. Her thesis is supported by a fellowship from the Bavarian Research Alliance and will focus on interactions between MSC and multiple myeloma. Read more here
Marietta Herrmann receives funding from the Max Buchner Forschungsstiftung!
We are very happy about the support of a collaborative research project with the Department of Tissue Engineering and Regenerative Medicine (TERM)
on “A modular fluid flow bioreactor system to investigate the role of oxygen tension in tumor invasion and metastasis".
Kim Koschitzki defended her MD thesis!
As first student in the group, Kim successfully completed her MD thesis entitled “Evaluation of preclinical animal models in bone tissue engineering and their success in clinical translation”. Congratulations!
New team members!
Slowly restarting our regular lab work, we are joined by new team members: Bianca Schlierf and Andrea Knorz will support the group as technical assistants, while Mert Ergin, enrolled in the Biofabrictaion Master program at University Bayreuth will perform his thesis with us.
Marietta Herrmann takes the turn as co-chair of the Musculoskeletal Center Würzburg (MCW).
Together with Prof. Torsten Blunk (Department of Trauma-, Hand-, Plastic- and Reconstructive Surgery), Marietta is following the long-term speaker Prof. Franz Jakob as speaker of the MCW.
Check out our new publication:
Pereira AR, Rudert M, Herrmann M. Decellularized human bone as a 3D model to study skeletal progenitor cells in a natural environment. Methods Cell Biol. 2020;157:123-141. doi: 10.1016/bs.mcb.2019.11.018. Epub 2019 Dec 31.
We are happy to have contributed to this great paper:
Melms H, Herrmann M, Förstner K, Bharti R, Schneider D, Mentrup B, Rudert M, Schlagenhauf U, Jakob F, Graser S. Novel molecular cues for dental defects in hypophosphatasia. Exp Cell Res. 2020 Apr 22:112026. doi: 10.1016/j.yexcr.2020.112026.
Noah Volkmann is joining our group.
Supported by a GSLS fellowship, Noah started to work on his MD thesis on the role of extracellular vesicles in promoting the immunomodulatory functions of MSC in bone healing. Read more here
Check out our new review article:
Herrmann M, Engelke K, Ebert R, Müller-Deubert S, Rudert M, Ziouti F, Jundt F, Felsenberg D, Jakob F. Interactions between Muscle and Bone—Where Physics Meets Biology, Biomolecules, 2020
Sofia Paulus starts her MD thesis.
After recently finishing her degree in dentistry at University in Heidelberg, Sofia is joining our lab working on dental aspects of the rare disease hypophosphatasia. Read more here
Finally arrived in our own lab!
Having improvised all the last years, we now finally settled in our own lab! What a relief!
We just received our new flow cytometer, an Attune NxT Cytometer with 4 laser. Having our own flow cytometer also means much less commuting to other facilities!
PhD fellowship by Bayerische Forschungsstiftung for Jovana Ilić
We are happy to announce that our application for a PhD fellowship was approved. Now we are looking forward to welcome PhD student Jovana Ilić from Belgrade, starting in March next year to work on a project entitled “Wechselspiel zwischen Seneszenz und Stammzelleigenschaften im Multiplen Myelom und im Stroma des Wirts – Implikationen für Therapie und Diagnostik” in collaboration with the ForTiTher consortium.
1st MuSkITYR Symposium in Günzburg
Marietta Herrmann led the organization of the first symposium of the MuSkITYRs.
Knochen, Muskeln, Gelenke – Update 2019 Berlin
MD student Janek Harder gave his first conference presentation with the title: “Comparison of cellular characteristics in bone marrow from acetabulum and proximal femur in patients with coxarthrosis”. He also won a travel fellowship!
DKOU 2019 – Berlin
One month later, we again visited Berlin, where Drenka Trivanović contributed a talk with the title “Immune regulatory and stem cell functions of human bone marrow mesenchymal stromal cells exposed to hematoma factors in vitro”. We also took the chance to meet up with members of the MuSkITYR network.
GSCN 2019 - Berlin
Drenka Trivanović and Marietta Herrmann joined the annual conference of the German Stem Cell Network in Berlin, where Drenka presented her work “Coordinated activation of mouse mesenchymal and hematopoietic progenitors in the early stage of bone healing” on a poster.
KCOS 2019 – Seoul
Marietta Herrmann was invited as a representative of the ECTS Academy to give a lecture on “Mesenchymal Stem Cells in Orthopedic Diseases” at the annual Korean Congress Osteoporosis and Spine.
Regeneration Research Symposium
We were delighted to participate with a keynote lecture given by Marietta Herrmann in an awesome symposium on Regeneration Research in Würzburg which was followed by the official opening of the Bernhard-Heine-Center for Locomotion Research by the Bavarian minister of science Bernd Sibler.
Best Graphical Abstract Award
Our paper “Approaches to mimic the complexity of the skeletal mesenchymal stem/stromal cell niche in vitro” won the eCM best graphical abstract January-June 2019 award!
TERMIS 2019 in Rhodes
Rita Pereira and Marietta Herrmann joined the EU-Chapter Meeting of TERMIS and Rita delivered a presentation on her work “A human bone-derived 3D scaffold for studying MSC interactions within the skeletal niche”.
ECTS 2019 in Budapest
Marietta Herrmann took part in this year`s annual meeting of the ECTS. Besides her involvement in the activities of the ECTS Academy, Marietta introduced the MuSkITYR network in the Next Generation Synergy Session and the group contributed a poster presentation.
Exciting times for the group, new team members - new rooms
After having been guests in the laboratories of the Orthopedic Center for Musculoskeltal Research for the past 2 years (a big thank you to the group for their hospitality), we have now moved to new rooms, where we closely collaborate with the Chair for Tissue Engineering and Regenerative Medicine (TERM), also here a big thank you for the warm welcome! At the same time 3 new team members started their theses in the group. Welcome to Janek Harder (MD Student), Jasmin Batani (B.Sc. Student) and Alexandra Maag (B.Sc. Student)!
Marietta Herrmann elected as chair of the MuSkiTYR, www.MuSkITYR.com, @MuSkITYR
One year after founding, the MuSkiTYR (MusculoSkeletal Interdisciplinary Translational Young Researchers) voted for new chair persons to take the lead in further shaping this young organization. Together with Felix Schmidt (Hamburg, co-chair), Marietta Herrmann will now take lead in running the network and organizing their acitivities.
Poster Price for the group @Osteologie 2019 in Frankfurt
At the annual Osteologie meeting we won the DVO Poster Price for our collaborative work with the AO Foundation Research Institut Davos. We are very grateful for this award and the great feedback!
Title: Evaluation of Preclinical Models for Testing of Bone Tissue Engineered Constructs - Need for Optimization
Authors: Stephan Zeiter, Kim Koschitzki, Mauro Alini, Maximilian Rudert, Marietta Herrmann