The main focus of our group is to understand how and why cancer cells develop specific dependencies on certain metabolic processes to sustain survival and growth. We study metabolic networks and how they are interconnected with each other in order to identify critical tumor specific liabilities that can be targeted for therapy. One process that potentially can be successfully exploited for cancer treatment is autophagy, a cellular self-digestion process that is tightly interwoven with cellular metabolism. Current work aims to unravel the unknown but essential metabolic functions of autophagy in cancer.
Rosenfeldt, M.T., O'Prey, J., Morton, J.P., Nixon, C., Mackay, G., Mrowinska, A., Au, A., Rai, T.S., Zheng, L., Ridgway, R., Adams, P.D., Anderson, K.I., Gottlieb, E., Sansom, O.J. and Ryan, K.M. (2013). p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504, 296-300.
Rosenfeldt M.T., Bell L.A., Long J.S., O'Prey J., Nixon C., Roberts F., Dufès C. and Ryan K.M. (2013). E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene. doi: 10.1038/onc.2013.470. [Epub ahead of print].
Laine A., Sihto H., Come C., Rosenfeldt M.T., Zwolinska A., Niemelä M., Khanna A., Chan E.K., Kähäri V.M., Kellokumpu-Lehtinen P.L., Sansom O.J., Evan G.I., Junttila M.R., Ryan K.M., Marine J.C., Joensuu H. and Westermarck J. (2013). Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov., 3, 182-97.
Rosenfeldt M.T., Nixon C., Liu E., Mah L.Y. and Ryan K.M. (2012). Analysis of macroautophagy by immunohistochemistry. Autophagy, 8, 963-9.
Rosenfeldt M.T. and Ryan K.M. (2011). The multiple roles of autophagy in cancer. Carcinogenesis, 32, 955-63.