Deutsch Intern
    Cancer Research


    Diagnosis of hereditary tumors or tumor syndromes (including the center for familial breast and ovarian cancer)

    Institute of Human Genetics (Biozentrum Hubland)

    Director: Prof. Dr. med. T. Haaf
    DNA lab: Dr. Gehrig
    Genetic Consultations: Dr. J. Schröder and Dr. med. (University of Belg.) N. Dragicevic

    Hereditary cancers can be noticed in a familial history, an early manifestation and / or as a characteristic Tumorspekrum. The cause in many cases are highly penetrable germline mutations in individual genes. About 10-20% of all cancers are genetic. For many autosomal dominant hereditary tumors, the genetic defect is known and detectable by NGS (Next Generation Sequencing). We use the TruSight Cancer Panel (Illumina), which contains 94 tumor genes, to detect these germline mutations. The most common tumor entities are gastrointestinal tumors, skin cancers, neuroendocrinological tumors, and familial breast and ovarian cancers. A tumor syndrome refers to a combination of different tumors that typically occur simultaneously or sequentially in a subject (eg, Cowden syndrome, Li-Fraumeni syndrome, Lynch syndrome, von Hippel Lindau syndrome, etc.).

    Affected persons at risk require special and long-term medical care compared to patients with a sporadic tumor disease. Of particular importance are surgical preventive measures and the concept of preventive oncology.

    An extremely important role is played by the possibility of predictive genetic testing among family members. The recurrence risk for first-degree relatives is 50%.

    We offer genetic counseling, assessment of the indications for genetic analysis, genetic testing, referral for early detection or further treatment to specialized centers.

    German consortium of familial breast and ovarian cancer, Würzburg center: http://www.humgen.biozentrum.uni-wuerzburg.de/patientenversorgung/brustkrebszentrum/