In our research group we are interested in the molecular mechanisms underlying the unrestricted growth of skin cancer cells. One particular focus lies on Merkel cell carcinoma (MCC) a rare but highly aggressive skin cancer with viral etiology. Indeed, the Merkel cell polyomavirus (MCPyV) is found monoclonally integrated in most of the MCC genomes, and MCPyV-positive tumor cell growth is dependent on the expression of viral oncoproteins, termed T antigens. Our group is interested in the molecular pathology of MCC and in particular in the interplay between viral and cellular proteins. Moreover, we are searching for new treatment options for MCC. Further skin cancers we are working on are melanoma and cutaneous T cell lymphoma.
Kervarrec T, Aljundi M, Appenzeller S, Samimi M, Maubec E, Cribier B, Deschamps L, Sarma B, Sarosi E-M, Berthon P, Levy A, Bousquet G, Tallet A, Touzé A, Guyétant S, Schrama D and Houben R. Polyomavirus-Positive Merkel Cell Carcinoma Derived from a Trichoblastoma Suggests an Epithelial Origin of this Merkel Cell Carcinoma. The Journal of investigative dermatology. 2019:S0022-0202X(0019)33387-33381.
Wobser M, Weber A, Glunz A, Tauch S, Seitz K, Butelmann T, Hesbacher S, Goebeler M, Bartz R, Kohlhof H, Schrama D and Houben R. Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells. Journal of hematology & oncology. 2019; 12(1):30.
Schrama D, Sarosi EM, Adam C, Ritter C, Kaemmerer U, Klopocki E, Konig EM, Utikal J, Becker JC and Houben R. Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration. International journal of cancer Journal international du cancer. 2019; 145(4):1020-1032.
Borst A, Haferkamp S, Grimm J, Rosch M, Zhu G, Guo S, Li C, Gao T, Meierjohann S, Schrama D and Houben R. BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines. Cancer Lett. 2017; 404:70-78.
Hesbacher S, Pfitzer L, Wiedorfer K, Angermeyer S, Borst A, Haferkamp S, Scholz CJ, Wobser M, Schrama D and Houben R. RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. Oncotarget. 2016; 7(22):32956-32968.
Schrama D, Hesbacher S, Angermeyer S, Schlosser A, Haferkamp S, Aue A, Adam C, Weber A, Schmidt M and Houben R. Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells. International journal of cancer Journal international du cancer. 2016; 138(5):1153-1162.