Our group is interested in the deregulation of cellular metabolic activity that is found in human tumors. Alterations in metabolic activity support the proliferation of cancer cells and are crucial for cancer development. Our work aims to understand the mechanisms that lead to metabolic changes in cancer cells and to identify specific metabolic processes that could be targeted for cancer therapy.
Miess, H.*, Dankworth, B.*, Gouw, AM., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, DW., Peck, B. and Schulze, A. (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma, Oncogene 2018 (in press) *equal contribution
Snaebjornsson MT, Schulze A. (2018) Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways, Exp Mol Med. 2018 Apr 16;50(4):34, doi: 10.1038/s12276-018-0065-6.
Klein-Hessling, S., Muhammad, K., Klein, M., Pusch, T., Rudolf, R., Floter, J., Qureischi, M., Beilhack, A., Vaeth, M., Kummerow, C., Backes, C., Schoppmeyer, R., Hahn, U., Hoth, M., Bopp, T., Berberich-Siebelt, F., Patra, A., Avots, A., Muller, N., Schulze, A. & Serfling, E. (2017) NFATc1 controls the cytotoxicity of CD8+ T cells, Nature Communication 8, 511.